The 15th International Conference on Monte Carlo Methods and Applications (MCM 2025) will be held at the Illinois Institute of Technology in Chicago. This biennial event serves as a central meeting point for experts in mathematics, statistics, computer science, operations research, and various application fields such as finance, chemistry, and physics. We extend our gratitude to IMSI for their generous sponsorship, acknowledging the crucial role of MCM 2025 in advancing research excellence and professional development. IMSI’s mission, centered on the rigorous application of mathematics and statistics to tackle pressing scientific and societal challenges, aligns closely with the conference’s objectives. The hosting of MCM 2025 by the Illinois Institute of Technology highlights the institution’s significance as it welcomes mathematicians, statisticians, computer scientists, and other specialists to explore the forefront of stochastic simulation and the theory and practice of Monte Carlo methods.